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- Title
Angiotensin‐converting enzyme activity and the ACE Alu polymorphism in autosomal dominant polycystic kidney disease.
- Authors
Schiavello, Tina; Burke, Valerie; Bogdanova, Nadia; Jasik, Piotr; Melsom, Steve; Boudville, Neil; Robertson, Ken; Angelicheva, Dora; Dworniczak, Bernd; Lemmens, Marta; Horst, Juergen; Todorov, Vassil; Dimitrakov, Dimitar; Sulowicz, Wladyslaw; Krasniak, Andrzej; Stompor, Tomasz; Beilin, Lawrence; Hallmayer, Joachim; Kalaydjieva, Luba; Thomas, Mark
- Abstract
Background. Previous studies concerning Alu I/D polymorphism in the ACE gene and ADPKD severity have used the Alu genotypes as a representative of the true biological variable, namely ACE activity. However, wide individual and ethnic differences in the proportion of variance in ACE activity explained by the I/D genotype may have confounded these studies. This investigation examines the association between ADPKD severity and ACE in terms of plasma enzyme activity and I/D genotypes in individuals from three different countries.
- Publication
Nephrology Dialysis Transplantation, 2001, Vol 16, Issue 12, p2323
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/16.12.2323