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- Title
In vitro evidence for differential involvement of CTGF, TGFβ, and PDGF‐BB in mesangial response to injury.
- Authors
Blom, Ingrid E.; van Dijk, Anette J.; Wieten, Lotte; Duran, Karen; Ito, Yasuhiko; Kleij, Livio; deNichilo, Mark; Rabelink, Ton J.; Weening, Jan J.; Aten, Jan; Goldschmeding, Roel
- Abstract
Background. Connective tissue growth factor (CTGF) is a profibrotic growth factor, which is upregulated in wound healing and renal fibrosis, including anti‐Thy‐1.1 nephritis. The kinetics of CTGF mRNA expression in anti‐Thy‐1.1 nephritis suggested that CTGF regulation might contribute to glomerular response to injury downstream of transforming growth factor‐β (TGFβ). In anti‐Thy‐1.1 nephritis the initial damage is followed by mesangial repair and limited sclerosis, which involves mesangial cell (MC) activation (α‐smooth‐muscle actin (αSMA) expression), proliferation, migration, and extracellular matrix production. The present in vitro study addresses the possible role of CTGF in these different aspects of mesangial response to injury, and how CTGF activity might relate to effects of TGFβ and platelet‐derived growth factor‐BB (PDGF‐BB).
- Publication
Nephrology Dialysis Transplantation, 2001, Vol 16, Issue 6, p1139
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/16.6.1139