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- Title
The penetration of rufloxacin into sites of potential infection in the respiratory tract.
- Authors
Wise, R.; Andrews, J; Imbimbo, B. P.; Greaves, I.; Honeybourne, D.
- Abstract
The concentrations of rufloxacin in the bronchial mucosal, pulmonary epithelial lining fluid and alveolar macrophages were determined in specimens obtained at fibreoptic bronchoscopy. A single oral dose of rufloxacin 400 mg was administered and the samples obtained in the following 72 h. The mean peak serum concentration was 3.56 mg/L, yet the agent was concentrated 1.8-fold in bronchial mucosa, 21.6-fold in alveolar macrophages and 7.7-fold in epithelial lining fluid (as measured by AUC ratios).
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1993, Vol 32, Issue 6, p861
- ISSN
0305-7453
- Publication type
journal article