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- Title
β-Lactam susceptibility of Haemophilus influenzae strains showing reduced susceptibility to cefuroxime.
- Authors
James, P. A.; Hossain, F. K.; Lewis, D. A.; White, D. G.
- Abstract
Minimum inhibitory concentrations of 13 -lactam antibiotics (ampicillin, amoxycillin, amoxycillin/clavulanate, imipenem, cefazolin, cefadroxil, cefaclor, cefuroxime, cefotaxime, cefepime, cefpirome, cefpodoxime and cefixime), were determined for 76 strains of -lactamase negative , isolated over a five year period (1985–1990) that gave reduced zones to cefuroxime on disc testing when compared to the control strain NCTC 11931. MIC values for all antibiotics (except imipenem) were approximately ten times higher than the MIC values for a susceptible control group. Increased resistance was not associated with any particular biotype, although three biotype III strains were highly resistant to imipenem. More than 50% of strains with reduced susceptibility to -lactam antibiotics were isolated from patients with chronic respiratory disease. Published data on the sputum concentration of each antibiotic were compared to the MIC values obtained for the susceptible and resistant strains.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1993, Vol 32, Issue 2, p239
- ISSN
0305-7453
- Publication type
Article