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- Title
Interaction between ciprofloxacin and vancomycin against staphylococci.
- Authors
Paton, James H.; Williams, Elizabeth W.; Paton, J H; Williams, E W
- Abstract
The interaction between ciprofloxacin and vancomycin against nine isolates of Staphylococcus epidermidis from cases of infective endocarditis and three strains of S. aureus was studied. Killing curves indicated the presence of antagonism in the early stages, the clinical significance of which is uncertain. No synergy was found and the combination therefore does not appear to offer any advantages over vancomycin alone for the treatment of staphylococcal infections.
- Subjects
COMBINATION drug therapy; CIPROFLOXACIN; DRUG interactions; MICROBIAL sensitivity tests; STAPHYLOCOCCUS; VANCOMYCIN; PHARMACODYNAMICS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1987, Vol 20, Issue 2, p251
- ISSN
0305-7453
- Publication type
journal article