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- Title
Activity of penicillin combined with an aminoglycoside against group B streptococci in vitro and in experimental endocarditis.
- Authors
Backes, Richard J.; Rouse, Mark S.; Henry, Nancy K.; Geraci, Joseph E.; Wilson, Walter R.
- Abstract
Group B streptococci were less susceptible to penicillin and to aminoglycosides with an inoculum size of 10–10 cfu/ml than with an inoculum size of 5.5×10–10 cfu/ml. With a rabbit model of experimental group B streptococcal endocarditis, after one or three days of therapy with procaine penicillin alone, the mean log cfu/g of valve vegetation was significantly lower (<0.01) than that of the control groups. After one day of therapy, procaine penicillin combined with streptomycin was significantly more effective (<0.01) than was treatment with procaine penicillin alone. There was no significant difference (>0.05) in the results of treatment of animals for one day with procaine penicillin combined with streptomycin compared with those of animals treated for three days with procaine penicillin alone.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1986, Vol 18, Issue 4, p491
- ISSN
0305-7453
- Publication type
Article