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- Title
A clinical comparison between Macrodantin and trimethoprim for prophylaxis in women with recurrent urinary infections.
- Authors
Brumfitt, W.; Smith, G. W.; Hamilton-Miller, J. M. T.; Gargan, R. A.; Hamilton-Miller, J M
- Abstract
Seventy-two patients with a history of at least three attacks of urinary infection in the previous 12 months were assigned randomly to long-term prophylaxis with 100 mg at night of either Macrodantin (34 patients) or trimethoprim (38 patients). The mean interval between symptomatic attacks while on either treatment was increased three-fold compared with the pretreatment period. Macrodantin was significantly more effective (P less than 0.05) at preventing bacteriuria. Prophylaxis was equally effective in patients with and without a radiological abnormality. Side effects were significantly more common (P less than 0.05) in the group taking Macrodantin. In patients taking trimethoprim acquisition of resistance by faecal coliforms occurred at a rate of about 5%/month, and breakthrough infections were almost exclusively caused by trimethoprim-resistant coliforms. No acquisition of resistance occurred in patients taking Macrodantin, and the few breakthrough infections noted were due to sensitive bacteria.
- Subjects
URINARY tract infection prevention; CLINICAL trials; COMPARATIVE studies; FECES; RESEARCH methodology; MEDICAL cooperation; RESEARCH; TRIMETHOPRIM; URINARY tract infections; EVALUATION research; RANDOMIZED controlled trials; NITROFURANTOIN; THERAPEUTICS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1985, Vol 16, Issue 1, p111
- ISSN
0305-7453
- Publication type
journal article