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- Title
Diz Altı Periferik Arter Hastalığında Albümin-Kreatinin Oranının Bir Yıllık Amputasyon Riski ile İlişkisi .
- Authors
ÖZBEYAZ, Nail Burak; AYDINYILMAZ, Faruk; GULIYEV, İlkin; GÖKALP, Gökhan; ALGÜL, Engin; PAMUKÇU, Hilal ERKEN; KALKAN, Kamuran
- Abstract
Objective: Our aim in this study is to determine the relationship between albumin‐creatinine ratio and amputation in 1‐year follow‐ups in patients with below‐knee peripheral artery disease who are not suitable for endovascular or surgical revascularization. Material and Method: 317 patients with below‐knee peripheral artery disease were included in the study retrospectively. Patients were grouped as amputated and non‐amputee based on 1‐year follow‐up results. Results: Advanced age, smoking and diabetes mellitus were found to be more common in amputated patients (p = <.001. p = .004, p= <.001, respectively). Hemoglobin (11.3±2.2 g/dL vs. 12.3±2.7 g/dL, p =.001), ejection fraction (46.7±8.1% vs. 49.5±8.5%, p = .014), al‐ bumin (3.7±0.5g/dL vs. 3.9±0.6 g/dL, p= .011) and albumin‐creatinine ratio (3.3±1.3 vs. 3.7±1.2, p= .003) were found to be lower in am‐ putated patients. By multiple regression analysis, age, active smoking, diabetes mellitus, aspartate aminotransferase, fasting blood glu‐ cose, and albumin‐creatinine ratio were found to be independent risk factors for amputation (odds ratio (95% confidence interval) 1.065 (1.024‐1.108), p=.002. odds ratio (95% confidence interval) 1.446(1.325‐1.769), p = .018, odds ratio (95% confidence interval) 1.721 (1.367‐1.877), p= .002. Odds ratio (95%CI) 1.117 (1.034‐1.365), p <.001. Odds ratio (95% confidence interval) 1.002 (1.001‐1.005), p=.041. Odds ratio (95% confidence interval) 0.383 (0.217‐0.733), p= .001, respectively). As a result of receiver operating characteristics curve analysis, the optimal cut‐off value for albumin‐creatinine ratio to predict the development of amputation was found to be 3.46 with a sensitivity of 63.8% and a specificity of 68.7% (area under the curve 0.650, 95% confidence interval: 0.571‐0.730, p< 0.001). Conclusion: Albumin‐creatinine ratio is associated with the risk of amputation in patients with below‐knee peripheral artery disease, which may develop despite optimal treatment within one year. This patient group can be recognized using albumin‐creatinine ratio, and morbidities can be reduced by applying more aggressive treatment regimens.
- Subjects
PERIPHERAL vascular diseases; RECEIVER operating characteristic curves; REVASCULARIZATION (Surgery); MULTIPLE regression analysis; LEG amputation; TRAUMATIC amputation
- Publication
MN Cardiology / MN Kardiyoloji, 2022, Vol 29, Issue 3, p144
- ISSN
1300-4778
- Publication type
Article