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- Title
Structure and signalling in the IL-17 receptor family.
- Authors
Gaffen, Sarah L.
- Abstract
Interleukin-17A (IL-17A), the hallmark cytokine of the newly defined T helper 17 (T(H)17) cell subset, has important roles in protecting the host against extracellular pathogens, but also promotes inflammatory pathology in autoimmune disease. IL-17A and its receptor (IL-17RA) are the founding members of a newly described family of cytokines and receptors that have unique structural features which distinguish them from other cytokine families. Research defining the signal transduction pathways induced by IL-17R family cytokines has lagged behind that of other cytokine families, but studies in the past 2 years have begun to delineate unusual functional motifs and new proximal signalling mediators used by the IL-17R family to mediate downstream events.
- Subjects
INTERLEUKINS; CYTOKINES; PATHOGENIC microorganisms; AUTOIMMUNE diseases; CELL receptors; CELLULAR immunity
- Publication
Nature Reviews Immunology, 2009, Vol 9, Issue 8, p556
- ISSN
1474-1733
- Publication type
journal article
- DOI
10.1038/nri2586