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- Title
Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice.
- Authors
Singer, Alfred; Adoro, Stanley; Jung-Hyun Park; Park, Jung-Hyun
- Abstract
Following successful gene rearrangement at alphabeta T-cell receptor (TCR) loci, developing thymocytes express both CD4 and CD8 co-receptors and undergo a life-or-death selection event, which is known as positive selection, to identify cells that express TCRs with potentially useful ligand specificities. Positively selected thymocytes must then differentiate into either CD4(+) helper T cells or CD8(+) cytotoxic T cells, a crucial decision known as CD4/CD8-lineage choice. In this Review, we summarize recent advances in our understanding of the cellular and molecular events involved in lineage-fate decision and discuss them in the context of the major models of CD4/CD8-lineage choice.
- Subjects
T cells; LYMPHOCYTES; CELL receptors; IMMUNOLOGY; MEDICAL sciences
- Publication
Nature Reviews Immunology, 2008, Vol 8, Issue 10, p788
- ISSN
1474-1733
- Publication type
journal article
- DOI
10.1038/nri2416