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- Title
Genetic Loss of miR-205 Causes Increased Mammary Gland Development.
- Authors
Cataldo, Alessandra; Cheung, Douglas G.; Hagan, John P.; Fassan, Matteo; Sandhu-Deol, Sukhinder; Croce, Carlo M.; Di Leva, Gianpiero; Iorio, Marilena V.
- Abstract
MiRNAs play crucial roles in a broad spectrum of biological processes, both physiological and pathological. Different reports implicate miR-205 in the control of breast stem cell properties. Differential miR-205 expression has been observed in different stages of mammary gland development and maturation. However, a functional role in this process has not been clearly demonstrated. We generated an miR-205 knockout in the FVB/N mouse strain, which is viable and characterized by enhanced mammary gland development. Indeed, mammary glands of miR-205−/− female mice at different ages (1.5 and 5.5 months) show increased outgrowth and branching. This evidence is consistent with our previously reported data demonstrating the direct miR-205-mediated targeting of HER3, a master regulator of mammary gland development, and the oncosuppressive activity of this microRNA in different types of breast cancer.
- Subjects
MICRORNA; MAMMARY glands; BREAST; BREAST cancer; STEM cells
- Publication
Non-Coding RNA, 2024, Vol 10, Issue 1, p4
- ISSN
2311-553X
- Publication type
Article
- DOI
10.3390/ncrna10010004