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- Title
Bacteriological profile and antibiotic susceptibility of neonatal sepsis in neonatal intensive care unit of a tertiary care centre.
- Authors
M. S., Shruthi; B., Sreenivasa; Kumar, Arun
- Abstract
BACKGROUND: Neonatal sepsis refers to infection involving bloodstream in newborns less than 28 days old. It continues to remain a leading cause of morbidity and mortality among newborns, especially in middle and low income countries. AIMS AND OBJECTIVES: study of bacteriological profile of sepsis and the antibiotic susceptibility of neonatal sepsis among newborns in neonatal intensive care unit. METHODS: This was a retrospective cross sectional study done at Basaveshwara medical college and Hospital, Chitradurga on 54 neonates with culture proven sepsis in newborns admitted to neonatal intensive care unit over one year period (August 2021 to August 2022) were identified using medical records database. All neonates with a clinical suspicion of sepsis with appositive blood culture were identified, their clinical details, maternal risk factors and laboratory data were included in the study. RESULTS: Of the 290 neonates admitted in neonatal intensive care unit, 54 had culture positive sepsis (18.6%). The majority were late onset sepsis (n = 39, 72.2%) and were among the preterm babies (n=30, 55.5%). Most bacterial isolates were gram negative predominantly klebsiella species (n= 19, 35.1%) klebsiella species showed resistance to commonly used antibiotics such as Oxacillin (100%) and Cefotaxime (90%). However they showed good susceptibility to Amikacin (100%) and Carbapenems (100%) among cultures with pseudomonas species, showed high resistance to Oxacillin (100%) and Carbapenems (80%) and showed good susceptibility to Piperacillin - Tazobactam (50%) and Amikacin (50%). CONCLUSION: Klebsiella and Psuedomonas species were the most common causes of neonatal sepsis in our study. Implementation of effective preventive strategies to combat the emergence of antibiotic resistance is urgently needed. We recommend a combination of Piperacillin-Tazobactam and Amikacin as the first line therapy and combination of Vancomycin and Carbapenem as the second line empirical therapy in our neonatal intensive care unit.
- Subjects
NEONATAL sepsis; NEONATAL intensive care units; PREMATURE infants; NEONATAL intensive care; GRAM-negative bacteria; MEDICAL record databases
- Publication
Indian Journal of Basic & Applied Medical Research, 2023, Vol 12, Issue 2, p58
- ISSN
2250-284X
- Publication type
Article
- DOI
10.36855/IJBAMR/2022/98215.55627