We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Age-specific reference ranges of serum anti-müllerian hormone in healthy women and its application in diagnosis of polycystic ovary syndrome: a population study.
- Authors
Li, HWR; He, Y‐L; Li, R; Wong, CYG; Sy, B; Lam, CW; Lam, KSL; Peng, H‐M; Mu, S; Schooling, M; Yeung, WSB; Ho, PC; Ng, EHY; He, Y-L; Lam, C W; Peng, H-M; Ho, P C
- Abstract
<bold>Objective: </bold>To establish the age-specific centiles of serum anti-müllerian hormone (AMH) levels in Chinese women, and to explore the use of multiples of median (MoM) AMH levels for the diagnosis of polycystic ovary syndrome (PCOS).<bold>Design: </bold>An observational study.<bold>Setting: </bold>University-affiliated hospitals and community clinics.<bold>Population: </bold>We included 3137 healthy women aged 20-44 years recruited prospectively or who had archived serum samples from previous research projects. Another validation cohort of 751 women with PCOS as well as ovulatory controls, which was a convenient sample of women attending for infertility or menstrual disorders, was also studied.<bold>Methods: </bold>The serum samples were assayed for AMH by the automated Access AMH assay.<bold>Main Outcome Measures: </bold>Age-specific reference ranges were constructed on the primary cohort with the Lambda-Mu-Sigma method. The MoM AMH of each subject in the validation cohort was calculated.<bold>Results: </bold>Centile curves of serum AMH level against age were established. MoM AMH was significantly higher in women with PCOS than in controls (P < 0.05). The area under the ROC curve was 0.852 (95% confidence interval [CI] 0.825-0.877) (P < 0.0001) for discriminating women with PCOS from ovulatory controls by MoM AMH.<bold>Conclusions: </bold>We established a set of year-by-year age-specific reference ranges of serum AMH levels in Chinese women. The MoM AMH derived from this set of reference ranges is a promising tool to replace antral follicle count in the diagnosis of PCOS.<bold>Tweetable Abstract: </bold>A set of age-specific reference ranges of AMH levels was established in Chinese women. Multiples of median AMH may be used to diagnose PCOS.
- Subjects
ANTI-Mullerian hormone; POLYCYSTIC ovary syndrome; CHINESE people; MENSTRUATION disorders; SERUM; COMPARATIVE studies; SEX hormones; RESEARCH methodology; MEDICAL cooperation; REFERENCE values; RESEARCH; SURVEYS; WOMEN'S health; EVALUATION research; RECEIVER operating characteristic curves
- Publication
BJOG: An International Journal of Obstetrics & Gynaecology, 2020, Vol 127, Issue 6, p720
- ISSN
1470-0328
- Publication type
journal article
- DOI
10.1111/1471-0528.16147