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- Title
Daño al ADN en neonatos de madres con sobrepeso.
- Authors
Pérez-Díaz, Cinthia Ivette; Zamora-Pérez, Ana Lourdes; Ortiz-García, Yveth Marlene; Sánchez-Urbina, Rocío; Avilés-Martínez, Karla Isis; Rulfo-Ibarra, Daniel Pérez
- Abstract
Introduction. Overweight in pregnancy is a chronic inflammatory process that increases the production of free radicals and oxidative stress. The increase of free radicals can cause ruptures to DNA and form micronuclei, their presence and frequency represents genomic damage, so the micronucleus assay in exfoliated cells is a specific biomarker to evaluate the exposure to genotoxic, teratogenic and carcinogenic compounds. Therefore, the objective of the present study was to determine the number of micronuclei in oral mucosa cells of mothers with normal weight, overweight and their newborns. Material and Methods. This was a cross-sectional study, mothers and their newborns were analyzed according to the mother's BMI. Cheek mucosa cells were sampled and stained with acridine orange for analysis under fluorescence microscopy. The non-parametric Mann Whitney U test of the SPSS statistical package was used to establish differences between the groups. Results. Overweight mothers and their newborns had a higher number of micronuclei compared to the normal weight group (p <0.05). Discussion. Our results show that there is DNA damage in overweight mothers and their newborns. It may be due to the inflammatory process characteristic of overweight and consequent increase of free radicals, showing that the intrauterine environment may be prone to imbalances between pro and anti oxidants that affect the development of the fetus, evidencing the teratogenic potential of obesity.
- Publication
Revista Médica MD, 2017, Vol 8, Issue 4, p141
- ISSN
2007-8188
- Publication type
Article