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- Title
Mining Database for The Clinical Significance, Prognostic Value and Expression of Mir-4746 In Hepatocellular Carcinoma.
- Authors
Altan, Zekiye; Şahin, Yunus; Karabulut, Aydın; Arslan, Ahmet
- Abstract
Introduction: MicroRNAs (miRNAs) are key regulators in the progression and development of hepatocellular carcinoma (HCC). In recent study the miR-4746 was found to be overexpressed in HCC, however, differential expression pattern and clinicopathological significance of miR-4746 in HCC remains unclear. In current study we aimed to evaluate expression profile, clinicopathological role and prognostic value of miR-4746 by using computational approaches. Materials and Methods: The expression profile of miR-4746 in various human cancers was determined using the dbDEMC database. Also, we used ENCORI/Starbase v2 and UALCAN databases to analyze miR-4746 expression level in HCC. Moreover, we investigated clinicopathological function of miR-4746 by using UALCAN database. Finally, survival analysis was performed to determine prognostic significance of miR-4746 in HCC by Kaplan-Meier plotter and ENCORI/Starbase v2 databases. Results: The miR-4746 had differential expression patterns in various human cancers and was significantly upregulated in HCC tissues compared with normal samples. Clinicopathological analysis revealed that, miR-4746 was differentially expressed in different clinical parameters including cancer stage, tumor grade, nodal metastasis status, TP53 mutation status, and patient's age. In addition, high expression of miR-4746 was significantly correlated with poor prognosis in HCC. Conclusion: Our findings indicated that miR-4746 might be as an oncogenic miRNA which were correlated with poor prognosis and worse clinicopathological outcomes. Furthermore, miR-4746 might have an important role in tumorigenesis of HCC and it might serve as potential prognostic biomarker.
- Subjects
HEPATOCELLULAR carcinoma; GENE expression; MICRORNA; SURVIVAL analysis (Biometry); NEOPLASTIC cell transformation
- Publication
Sakarya Tıp Dergisi, 2023, Vol 13, Issue 2, p217
- ISSN
2146-2585
- Publication type
Article
- DOI
10.31832/smj.1187165