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- Title
HISTOMORPHOLOGY OF BONE LESIONS: EVIDENCE OF A SKELETAL TREPONEMATOSIS FROM 15<sup>TH</sup> -19<sup>TH</sup> CENTURIES, IN IASI, ROMANIA.
- Authors
PETRARU, OZANA-MARIA; POPOVICI, MARIANA; NEAGU, ANCA-NARCISA; GROZA, VASILICA-MONICA; BEJENARU, LUMINIȚA
- Abstract
The analysis of archaeological human bone tissue can provide valuable information on cellular activity related to diseases from the past. The application of histology has become an essential and integral part in the study of human dry bone pathologies. Although paleopathology of human remains has been intensely studied, particularly by a macroscopical approach, the microscopical analysis of the affected archaeological bone tissue is an issue that has not been addressed at the same scale. This study represents the first paleohistological approach of some pathological lesions suggestive for syphilis from Romania. The aim of this study is to describe the paleohistological features (i.e., periosteal new bone formation and adjacent compact bone tissue morphology) of typical syphilitic changes in the long bones of a human skeleton (R30) from the 15th -19th centuries, discovered at the Roman Catholic Cathedral from Iaşi. The tissue material was subjected to the methodology for histological examination of dry bone samples. Samples were cleaned in multiple sonic baths and embedded in Buehler EpoThin 2 epoxy resin. The sections were ground and polished using carbide paper and visualized through a Confocal Laser Scanning Microscope CLSM--Leica TCS SPE DM. The preservation of the archaeological samples was assessed using the Oxford Histological Index stages. The taphonomic evaluation showed that the bone samples were very well preserved in archaeological context. During the microscopic analysis periosteal, new bone formation (e.g., polsters) and grenzlinie or remnants of these structures were identified, suggesting an inflammatory process. Sinuous lacunae were also observed in the compact bone tissue, indicating an osteolytic activity.
- Subjects
ROMANIA; HUMAN skeleton; PALEOPATHOLOGY; COMPACT bone; MICROSCOPY; EPOXY resins; BONE growth; CATHOLICS
- Publication
Journal of Experimental & Molecular Biology, 2022, Vol 23, Issue 2, p13
- ISSN
2601-6974
- Publication type
Article
- DOI
10.47743/jemb-2022-23-2