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- Title
In Brief.
- Abstract
The article presents information on various articles related to cancer research, previously published in different journals. The focus of cancer epigenetics has mainly been on aberrant DNA methylation, but researchers now highlight the importance of histone modifications. They find altered histone modifications in a range of cancer cell lines and primary tumors. Patients with high levels of Polo-like kinase 1 are less likely to survive than those with lower levels. Researchers have found that markers of an activated DNA-damage response are commonly expressed in early precursor lesions, and are induced in vitro following the expression of oncogenes that deregulate DNA replication.
- Subjects
CANCER research; CANCER genetics; METHYLATION; DNA damage; CANCER cells; DNA replication
- Publication
Nature Reviews Cancer, 2005, Vol 5, Issue 5, p335
- ISSN
1474-175X
- Publication type
Article
- DOI
10.1038/nrc1621