We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Tropylium-promoted prenylation reactions of phenols in continuous flow.
- Authors
Omoregbee, Klaus; Luc, Kevin N. H.; Dinh, An H.; Nguyen, Thanh Vinh
- Abstract
2-Dimethylchroman framework occurs in many complex natural and synthetic compounds which show various types of biological activities such as antitumor, anticancer, antihypertensive, antioxidant and antithrombotic. Herein, we report an organocatalytic approach to the synthesis of 2,2-dimethylchromans where tropylium tetrafluoroborate was used as an organic Lewis acid catalyst for metal-free prenylation reactions of phenols. This method was amenable to continuous flow chemistry to enable an inexpensive pathway to access 2,2-dimethylchromans on multiple-gram scale with short reaction times, high efficiencies and simple product purification.
- Subjects
ISOPRENYLATION; PHENOLS; FLOW chemistry; ACID catalysts; ORGANIC acids
- Publication
Journal of Flow Chemistry, 2020, Vol 10, Issue 1, p161
- ISSN
2062-249X
- Publication type
Article
- DOI
10.1007/s41981-020-00082-w