We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Clearance time of Nicarbazin in contaminated tissues in laying hens.
- Authors
Lin, Y. C.; Chiu, C. H.; Pao, L. H.; Chen, M. S.; Wang, S. Y.
- Abstract
Nicarbazin (NCZ) is an anticoccidial drug commonly used in broiler. Although it is not allowed to be used in laying hens, drug residue incidents are still often heard. In order to understand the clearance time for the contaminated tissues, 1, 10, and 100 ppm NCZ were added to the feed, then fed to hens for 7 days. Egg quality, NCZ residues were observed for eggs and tissues (liver, muscle, serum) weekly after drug withdrawal. The results show that medium and high doses of NCZ reduced the quality of eggshells and lighten the color. NCZ remained high in all tissues on the day of drug withdrawal, then declined rapidly. Except for eggs, NCZ in other tissues dropped to nearly zero one week after the drug withdrawal, but it would still take two weeks to reach zero detection, and even three weeks for the high-dose group. Eggs need to wait until the 7th day before NCZ began to decline, but it will take 11 days to reach nondetectable level. Occasionally, a single egg was still detected with trace residues. In summary, it is recommended that the safety period of the contaminated eggs should base on the NCZ levels, but at least must wait for more than 11 days.
- Subjects
NICARBAZIN; DRUG residues; DRUG withdrawal symptoms; EGGSHELLS; HENS
- Publication
Journal of the Chinese Society of Animal Science, 2021, Vol 50, p162
- ISSN
0253-9187
- Publication type
Article