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- Title
靶向TRPA1 通道的药物开发研究进展.
- Authors
梁珂维; 王康; 蔡芬; 梅凯迪; 王媛媛; 姚镜
- Abstract
The Transient receptor potential (TRP) channel is a non selective cation channel, and is widely distributed in neuronal and non neuronal cells. As a subtype of TRP channel, TRPA1 is a temperature sensitive TRP channel which temperature activation threshold is related to species. TRPA1 in mouse is activated by cold temperature (<17 °C), however TRPA1 in the green lizard is sensitive to warmtemperature (35.8 °C). In addition to the response to the temperature, TRPA1 can also be activated by chemical stimuli, mechanical stimulation and other physical and chemical means. A recent study shows that a gain-of-function mutation in TRPA1 can lead to familial paroxysmal pain syndrome. Due to TRPA1 has been proposed to function in many physiological and pathological processes such as temperature perception, pain producing, asthma and itching, TRPA1 has become one of the most intensively studied ion channels and attracted wide attention. In this review, we summarize the biophysical characteristics of TRPA1 channels, and discuss recent advances in our understanding of TRPA1 physiology, pharmacology, and molecular function in order to provide theoretical basis for clinical treatment of related diseases.
- Subjects
TRP channels; ACTIVATION energy; COLD (Temperature); ION channels; GAIN-of-function mutations; ITCHING
- Publication
Progress in Modern Biomedicine, 2019, Vol 19, Issue 5, p996
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2019.05.045