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- Title
介入治疗联合降血清同型半胱氨酸治疗对冠心病患者血清微炎症 介质水平的影响
- Authors
王蕊; 叶莎; 邵玉玲; 惠玲玲; 王瑾
- Abstract
Objective: To investigate the effect of interventional therapy combined with serum homocysteine lowering on the serum levels of microinflainmatory mediators of patients with coronary heart disease (CHD). Methods: 80 patients with CHD who were treated in our hospital from January 2014 to January 2017 were randomly divided into the study group and the control group, with 41 cases in each group. Patients in the control group were treated with clopidogrel. Aspirin, statins and β-blockers and other conventional medication, the study group of patients in the conventional treatment based on the combination of folic acid B group of vitamin down-type cysteine treatment. All the patients were continuously treated for six months, the serum interleukin-6*(IL-6), c-reactive protein (CRP). calcitonin (PCT). soluble intercellular adhesion factor 1 (ICAM-1), X terminal brain natriuretic peptide precursor levels (NTpro-BNP) and homocysteine (Hey) levels were compared between two groups of patients before and after treatment. Results: There was no significant difference in the levels of serum Hey, L-6, CRP, PCT, ICAM-1 and NTpro-BNP between the two groups before treatment(P>0.05). After treatment, the serum Hey, L-6, CRP, PCT, ICAM-1 and NTpro-BNP levels of both groups were significantly lower than before treatment, and the above indexes were significantly lower in the study group than those in the control group (P<0.05). Conclusions: Interventional therapy combined with serum homocysteine lowering was effective in treating CHD patients, it reduced the mflammatory response and effectively protected the cardiac function.
- Publication
Progress in Modern Biomedicine, 2018, Vol 18, Issue 12, p2351
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2018.12.032