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- Title
Clinical Benefit for Patients with Non-Small Cell Lung Cancer Enrolled in Phase I Trials.
- Authors
Levy, antonin; Gomez-Roca, Carlos; Massard, Christophe; Planchard, David; albiges, Laurence; Bahleda, Ratislav; Bourgier, Céline; Deutsch, Eric; Soria, Jean Charles; Besse, Benjamin
- Abstract
Aim: To analyze the clinical features and outcomes of advanced non-small cell lung cancer (NSCLC) patients treated in phase I trials. Patients and Methods: The clinical characteristics, efficacy and toxicity data of 70 pretreated NSCLC patients enrolled in 17 phase I trials between January 2005 and June 2010 were analyzed at our institution. Results: The histological types were: adenocarcinoma (79%), squamous cell carcinoma (13%), and others. Patients received a median number of 3 prior lines of treatment before inclusion. 1 complete response (CR), 11 (16%) partial responses (PRs), and 29 (41%) stable diseases (SDs) were observed (according to Response Evaluation Criteria in Solid Tumors (RECIST)). The median overall survival (OS) time was 18 months and the median progression-free survival (PFS) time was 4.1 months. The median PFS of these patients within their prior therapy line before phase I inclusion was 4.3 months. A performance status score of 0 and the number of prior lines of treatment were significant for OS and PFS in multivariate analysis, respectively. Grade 3/4 toxicities were observed in 20 (27%) patients, and there was 1 treatment-related death. Conclusion: Patients in good general condition and with limited pretreatment derived an improved benefit, suggesting that phase I studies may be a valid option for pretreated NSCLC patients.
- Publication
Oncology Research & Treatment, 2013, Vol 36, Issue 6, p357
- ISSN
2296-5270
- Publication type
Article
- DOI
10.1159/000351257