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- Title
Optimal Medical Therapy Prescription in Patients with Acute Coronary Syndrome in the Netherlands: A Multicenter Pilot Registry.
- Authors
Hoedemaker, Niels P. G.; de Winter, Robbert J.; Hof, Arnoud van't; Kolkman, Evelien; Damman, Peter
- Abstract
Background: Unlike neighboring countries, the Netherlands does not have a national acute coronary syndrome (ACS) registry to evaluate quality of care. Objective: We conducted a pilot registry in two hospitals to assess the prescription of guideline-recommended therapies in Dutch patients with ACS. Methods: We included all consecutive patients with ST-elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI) (n = 1309) admitted to two Dutch percutaneous coronary intervention centers between March 2015 and February 2016. We collected follow-up medication use and reasons for discontinuation at discharge and 1, 6, and 12 months post-discharge. We assessed the use of optimal medical therapy (OMT), defined as the combined prescription of aspirin, P2Y12 inhibitors, statins, β-blockers, and angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers. Results: OMT prescription was 43.2% at discharge, 60.1% at 1 month, and 28.7% at 12 months. At 1 month, OMT prescription was significantly lower in patients with NSTEMI (51.8 vs. 65.7% for STEMI; p < 0.001). OMT prescription was lower in women (6 months: 55.4 vs. 62.0%, p = 0.036) and in elderly patients. Conclusion: In this pilot study that aimed to extend a national Dutch ACS registry to patients with STEMI and NSTEMI, OMT prescription was comparable to that in other local registries, was lower in women and patients with NSTEMI, and decreased with increasing age.
- Subjects
NETHERLANDS; CLINICAL drug trials; HOSPITALS; REPORTING of diseases; RESEARCH; PILOT projects; PATIENT aftercare; STATINS (Cardiovascular agents); COMBINATION drug therapy; AGE distribution; ACUTE coronary syndrome; MEDICAL cooperation; ACE inhibitors; MYOCARDIAL infarction; MEDICAL protocols; ADRENERGIC beta blockers; SEX distribution; DRUG prescribing; ASPIRIN; PLATELET aggregation inhibitors; DESCRIPTIVE statistics; PHYSICIAN practice patterns; PATIENT compliance; ANGIOTENSIN receptors; MEDICAL prescriptions; DISCHARGE planning
- Publication
American Journal of Cardiovascular Drugs, 2021, Vol 21, Issue 2, p219
- ISSN
1175-3277
- Publication type
Article
- DOI
10.1007/s40256-020-00427-9