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- Title
Clinical Utility of Pharmacy-Based Adherence Measurement in Predicting Virologic Outcomes in an Adult HIV-Infected Cohort in Jos, North Central Nigeria.
- Authors
Abah, Isaac Okoh; Ojeh, Victor Bazim; Ugoagwu, Placid; Musa, Jonah; Agaba, Patricia Aladi; Agbaji, Oche; Okonkwo, Prosper
- Abstract
<bold>Objectives: </bold>We examined the association between adherence to drug-refill visits and virologic outcomes in a cohort of HIV-infected adults on combination antiretroviral therapy (cART) in North Central Nigeria.<bold>Methods: </bold>Retrospectively, 588 HIV-infected, cART-naive adults (aged ≥15 years), initiated on first-line ART between 2009 and 2010 at the Jos University Teaching Hospital, were evaluated. Association between adherence to drug-refill visits, virologic (viral load>1000 copies/mL), and immunologic failure was assessed using multivariable logistic regression.<bold>Results: </bold>After a median of 12 months on cART, 16% (n=94) and 10% (n=59) of patients had virologic and immunologic failures, respectively. In the final multivariable model, suboptimal adherence to drug-refill visits was a significant predictor of both virologic (adjusted odds ratio [AOR] 1.6; 95% confidence interval [CI]:1.2-2.3) and immunologic (AOR 1.92; 95% CI:1.06-3.49) failures.<bold>Conclusion: </bold>Adherence to drug refill is a useful predictor of successful virologic control and could be utilized for routine monitoring of adherence to cART in our clinical setting.
- Subjects
PATIENT compliance; HIV-positive persons; COHORT analysis; ANTIRETROVIRAL agents; THERAPEUTICS; HIV infections
- Publication
Journal of the International Association of Providers of AIDS Care, 2016, Vol 15, Issue 1, p77
- ISSN
2325-9582
- Publication type
journal article
- DOI
10.1177/2325957414539197