We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Nontuberculous mycobacteria in China: incidence and antimicrobial resistance spectrum from a nationwide survey.
- Authors
Liu, Chun-Fa; Song, Yi-Meng; He, Wen-Cong; Liu, Dong-Xin; He, Ping; Bao, Jing-Jing; Wang, Xin-Yang; Li, Yan-Ming; Zhao, Yan-Lin
- Abstract
Background: Information on the prevalence and resistance spectrum of nontuberculous mycobacteria (NTM) in China is mainly based on regional or local data. To estimate the proportion of NTM cases in China, a national survey of NTM pulmonary disease was carried out based on acid-fast positive sputum samples collected in 2013. Methods: Sputum samples collected from enrolled presumptive cases in 72 nationwide tuberculosis surveillance sites from the 31 provinces in the mainland of China were cultured using L-J medium at the National tuberculosis reference laboratory (NTRL). MALDI-TOF MS identified the species of re-cultured strains, and minimal inhibitory concentrations (MICs) were determined to evaluate the drug susceptibility of NTM isolates. Data analysis used statistical software SPSS version 22.0 for Windows statistical package. Results: Of 4917 mycobacterial isolates cultured, 6.4% [317/4917, 95% confidence interval (CI) 5.8%–7.2%] were confirmed as NTM, among which 7.7% (287/3709, 95% CI 6.9%–8.6%) were from the southern region. In inland and coastal China, 87.7% (95% CI 78.7%–93.2%) and 50.0% (95% CI 43.7%–56.3%) of isolates, respectively, were slow-growing mycobacteria (SGM), with the remaining rapid growing mycobacteria (RGM). A total of 29 species were detected, Mycobacterium abscessus had higher clarithromycin-inducible resistance rates than M. massiliense (65.67% vs 2.22%). M. kansasii presented lower resistance rates in linezolid and moxifloxacin than M. avium-intracellulare complex (3.23% vs 66.67%, 0 vs 47.22%) and other SGM (3.23% vs 38%, 0 vs 26%). Conclusions: More NTM pulmonary disease was observed in the south and coastal China (P < 0.01). SGM was widely distributed, and more RGM are present in southern and coastal China (P < 0.01). The antimicrobial resistance spectrum of different NTM species was significantly different and accurate species identification would be facilitated to NTM pulmonary disease treatment.
- Subjects
CHINA; DRUG resistance in microorganisms; MYCOBACTERIA; MICROSOFT Windows (Operating system); LUNG diseases; STATISTICAL software; THERAPEUTICS; FUEL reduction (Wildfire prevention)
- Publication
Infectious Diseases of Poverty, 2021, Vol 10, Issue 1, p1
- ISSN
2049-9957
- Publication type
Article
- DOI
10.1186/s40249-021-00844-1