We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Dissecting Genetic Mechanisms of Differential Locomotion, Depression, and Allodynia after Spinal Cord Injury in Three Mouse Strains.
- Authors
Yang, Wendy W.; Matyas, Jessica J.; Li, Yun; Lee, Hangnoh; Lei, Zhuofan; Renn, Cynthia L.; Faden, Alan I.; Dorsey, Susan G.; Wu, Junfang
- Abstract
Strain differences have been reported for motor behaviors, and only a subset of spinal cord injury (SCI) patients develop neuropathic pain, implicating genetic or genomic contribution to this condition. Here, we evaluated neuropsychiatric behaviors in A/J, BALB/c, and C57BL/6 male mice and tested genetic or genomic alterations following SCI. A/J and BALB/c naive mice showed significantly less locomotor activity and greater anxiety-like behavior than C57BL/6 mice. Although SCI elicited locomotor dysfunction, C57BL/6 and A/J mice showed the best and the worst post-traumatic recovery, respectively. Mild (m)-SCI mice showed deficits in gait dynamics. All moderate/severe SCI mice exhibited similar degrees of anxiety/depression. mSCI in BALB/c and A/J mice resulted in depression, whereas C57BL/6 mice did not exhibit depression. mSCI mice had significantly lower mechanical thresholds than their controls, indicating high cutaneous hypersensitivity. C57BL/6, but not A/J and BLAB/c mice, showed significantly lower heat thresholds than their controls. C57BL/6 mice exhibited spontaneous pain. RNAseq showed that genes in immune responses and wound healing were upregulated, although A/J mice showed the largest increase. The cell cycle and the truncated isoform of trkB genes were robustly elevated in SCI mice. Thus, different genomics are associated with post-traumatic recovery, underscoring the likely importance of genetic factors in SCI.
- Subjects
SPINAL cord injuries; ANIMAL locomotion; ALLODYNIA; LABORATORY mice; MICE
- Publication
Cells (2073-4409), 2024, Vol 13, Issue 9, p759
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells13090759