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- Title
Pseudomonas aeruginosa Cytotoxins: Mechanisms of Cytotoxicity and Impact on Inflammatory Responses.
- Authors
Wood, Stephen J.; Goldufsky, Josef W.; Seu, Michelle Y.; Dorafshar, Amir H.; Shafikhani, Sasha H.
- Abstract
Pseudomonas aeruginosa is one of the most virulent opportunistic Gram-negative bacterial pathogens in humans. It causes many acute and chronic infections with morbidity and mortality rates as high as 40%. P. aeruginosa owes its pathogenic versatility to a large arsenal of cell-associated and secreted virulence factors which enable this pathogen to colonize various niches within hosts and protect it from host innate immune defenses. Induction of cytotoxicity in target host cells is a major virulence strategy for P. aeruginosa during the course of infection. P. aeruginosa has invested heavily in this strategy, as manifested by a plethora of cytotoxins that can induce various forms of cell death in target host cells. In this review, we provide an in-depth review of P. aeruginosa cytotoxins based on their mechanisms of cytotoxicity and the possible consequences of their cytotoxicity on host immune responses.
- Subjects
CYTOTOXINS; INFLAMMATION; GRAM-negative bacteria; CELL death; DEATH rate; PSEUDOMONAS aeruginosa; MICROCYSTIS aeruginosa
- Publication
Cells (2073-4409), 2023, Vol 12, Issue 1, p195
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells12010195