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- Title
Centella asiatica -Derived Endothelial Paracrine Restores Epithelial Barrier Dysfunction in Radiation-Induced Enteritis.
- Authors
Kwak, Seo Young; Jang, Won Il; Lee, Seung Bum; Kim, Min-Jung; Park, Sunhoo; Cho, Sang Sik; Kim, Hyewon; Lee, Sun-Joo; Shim, Sehwan; Jang, Hyosun
- Abstract
Radiation-induced enteritis is frequently observed following radiotherapy for cancer or occurs due to radiation exposure in a nuclear accident. The loss of the epithelial integrity leads to 'leaky gut', so recovery of damaged epithelium is an important strategy in therapeutic trials. Centella asiatica (CA), a traditional herbal medicine, is widely used for wound healing by protecting against endothelial damage. In this study, we investigated the radio-mitigating effect of CA, focusing on the crosstalk between endothelial and epithelial cells. CA treatment relieved radiation-induced endothelial dysfunction and mitigated radiation-induced enteritis. In particular, treatment of the conditioned media from CA-treated irradiated endothelial cells recovered radiation-induced epithelial barrier damage. We also determined that epidermal growth factor (EGF) is a critical factor secreted by CA-treated irradiated endothelial cells. Treatment with EGF effectively improved the radiation-induced epithelial barrier dysfunction. We also identified the therapeutic effects of CA-induced endothelial paracrine in a radiation-induced enteritis mouse model with epithelial barrier restoration. Otherwise, CA treatment did not show radioprotective effects on colorectal tumors in vivo. We showed therapeutic effects of CA on radiation-induced enteritis, with the recovery of endothelial and epithelial dysfunction. Thus, our findings suggest that CA is an effective radio-mitigator against radiation-induced enteritis.
- Subjects
CENTELLA asiatica; ENTERITIS; EPIDERMAL growth factor; ENDOTHELIAL cells; RADIATION exposure; COLON tumors; EPITHELIAL cells
- Publication
Cells (2073-4409), 2022, Vol 11, Issue 16, p2544
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells11162544