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- Title
Assessing Therapeutic Efficacy in Real-time by Hyperpolarized Magnetic Resonance Metabolic Imaging.
- Authors
Dutta, Prasanta; Salzillo, Travis C.; Pudakalakatti, Shivanand; Gammon, Seth T.; Kaipparettu, Benny A.; McAllister, Florencia; Wagner, Shawn; Frigo, Daniel E.; Logothetis, Christopher J.; Zacharias, Niki M.; Bhattacharya, Pratip K.
- Abstract
Precisely measuring tumor-associated alterations in metabolism clinically will enable the efficient assessment of therapeutic responses. Advances in imaging technologies can exploit the differences in cancer-associated cell metabolism as compared to normal tissue metabolism, linking changes in target metabolism to therapeutic efficacy. Metabolic imaging by Positron Emission Tomography (PET) employing 2-fluoro-deoxy-glucose ([18F]FDG) has been used as a routine diagnostic tool in the clinic. Recently developed hyperpolarized Magnetic Resonance (HP-MR), which radically increases the sensitivity of conventional MRI, has created a renewed interest in functional and metabolic imaging. The successful translation of this technique to the clinic was achieved recently with measurements of 13C-pyruvate metabolism. Here, we review the potential clinical roles for metabolic imaging with hyperpolarized MRI as applied in assessing therapeutic intervention in different cancer systems.
- Subjects
POSITRON emission tomography; MAGNETIC resonance imaging; TISSUE metabolism; CELL metabolism; MAGNETIC resonance
- Publication
Cells (2073-4409), 2019, Vol 8, Issue 4, p340
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells8040340