We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Exploring Parkinson's Disease-Associated Depression: Role of Inflammation on the Noradrenergic and Serotonergic Pathways.
- Authors
Sampaio, Tuane Bazanella; Schamne, Marissa Giovanna; Santos, Jean Rodrigo; Ferro, Marcelo Machado; Miyoshi, Edmar; Prediger, Rui Daniel
- Abstract
Parkinson's disease (PD) is a multifactorial disease, with genetic and environmental factors contributing to the disease onset. Classically, PD is a movement disorder characterized by the loss of dopaminergic neurons in the nigrostriatal pathway and intraneuronal aggregates mainly constituted of the protein α-synuclein. However, PD patients also display non-motor symptoms, including depression, which have been linked to functional abnormalities of non-dopaminergic neurons, including serotonergic and noradrenergic ones. Thus, through this comprehensive literature review, we shed light on the noradrenergic and serotonergic impairment linked to depression in PD, focusing on the putative involvement of inflammatory mechanisms.
- Subjects
PARKINSON'S disease; LITERATURE reviews; DOPAMINERGIC neurons; MENTAL depression; MOVEMENT disorders
- Publication
Brain Sciences (2076-3425), 2024, Vol 14, Issue 1, p100
- ISSN
2076-3425
- Publication type
Article
- DOI
10.3390/brainsci14010100