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- Title
FLAIRectomy: Resecting beyond the Contrast Margin for Glioblastoma.
- Authors
Haddad, Alexander F.; Young, Jacob S.; Morshed, Ramin A.; Berger, Mitchel S.
- Abstract
The standard of care for isocitrate dehydrogenase (IDH)-wildtype glioblastoma (GBM) is maximal resection followed by chemotherapy and radiation. Studies investigating the resection of GBM have primarily focused on the contrast enhancing portion of the tumor on magnetic resonance imaging. Histopathological studies, however, have demonstrated tumor infiltration within peri-tumoral fluid-attenuated inversion recovery (FLAIR) abnormalities, which is often not resected. The histopathology of FLAIR and local recurrence patterns of GBM have prompted interest in the resection of peri-tumoral FLAIR, or FLAIRectomy. To this point, recent studies have suggested a significant survival benefit associated with safe peri-tumoral FLAIR resection. In this review, we discuss the evidence surrounding the composition of peri-tumoral FLAIR, outcomes associated with FLAIRectomy, future directions of the field, and potential implications for patients.
- Subjects
ISOCITRATE dehydrogenase; GLIOBLASTOMA multiforme; MAGNETIC resonance imaging
- Publication
Brain Sciences (2076-3425), 2022, Vol 12, Issue 5, p544
- ISSN
2076-3425
- Publication type
Article
- DOI
10.3390/brainsci12050544