We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cornification defect in the Golden retriever: clinical, histopathological, ultrastructural and genetic characterisation.
- Authors
Cadiergues, Marie-Christine; Patel, Anita; Shearer, David H.; Fermor, Ruth; Miah, Suhel; Hendricks, Anke
- Abstract
Veterinarians have recognised a nonpruritic skin disease in the Golden retriever breed characterised by excessive scaling of large, variably pigmented flakes of skin in otherwise healthy dogs. This prospective case series describes clinical, histopathological, ultrastructural and genetic features of this cornification defect in 17 affected dogs. The condition affects young dogs of either sex and is characterised by symmetrical, predominantly ventro-lateral scaling and hyperpigmentation of the trunk. Histopathological and ultrastructural changes of the stratum corneum are suggestive of delayed degradation of corneodesmosomes. A genetic aetiology is proposed and a single-trait autosomal recessive mode of inheritance discussed.
- Subjects
GOLDEN retriever; ANIMAL specialists; DOG diseases; ALLERGY in dogs; PIGMENTATION disorders; DISEASES
- Publication
Veterinary Dermatology, 2008, Vol 19, Issue 3, p120
- ISSN
0959-4493
- Publication type
Article
- DOI
10.1111/j.1365-3164.2008.00667.x