We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Abstracts from the American Academy of Veterinary Dermatology and American College of Veterinary Dermatology Annual Meeting. Monterey, CA, 9-13 April 2003.
- Authors
Beco, L.; Heimann, M.; Olivry, T.
- Abstract
A verrucous and crusted papular dermatitis affecting mainly the shoulder and dorsal neck of a cat was diagnosed as 'reactive perforating collagenosis'. Microscopic observation of skin biopsies revealed degenerated collagen bundles, fibrin, eosinophils and neutrophils extending from the dermis through the epidermis in a perforating pattern. The purpose of this study was to compare the efficacy of different treatment regimens known to interfere with collagen synthesis. Oral vitamin C (100 mg kg[sup -1] every 12 h for 6 weeks and then 200 mg kg[sup -1] every 12 h for 1 month) was not effective. Oral prednisolone (2 mg kg[sup -1] every 12 h for 15 days followed by 1 mg kg[sup -1] every 24 h for 15 days) was not helpful. All lesions were shaved 'at skin level to enhance penetration of various topical medications. The first trial compared topical betamethasone ointment 'applied twice daily to one shoulder leaving the second shoulder untreated for 6 weeks. All lesions recurred on the untreated shoulder but not on betamethasone-treated areas. A second trial compared the efficacy of topical betamethasone, halofuginone (a type I collagen inhibitor) and fucidic acid (antibiotic control) ointments. Each medication was applied, twice daily, simultaneously on three different sites, for 100 days. Betamethasone induced almost complete healing of the lesions but skin atrophy and delayed hair regrowth were observed. Halofuginone was equally effective but without any detectable adverse drug effects. Fucidic acid application was completely ineffective. These observations lead to the hypothesis that reactive perforating collagenosis could be caused by abnormal collagen synthesis, and be treated with drugs inhibiting collagen formation.
- Subjects
UNITED States; VETERINARY dermatology
- Publication
Veterinary Dermatology, 2003, Vol 14, Issue 4, p210
- ISSN
0959-4493
- Publication type
Article
- DOI
10.1046/j.1365-3164.2003.t01-1-00349.x