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- Title
Effect of Promising Antitumor Phenolic Antioxidant Anphen Sodium on the BCL-2 Family Proteins.
- Authors
Mil, E. M.; Erokhin, V. N.; Binyukov, V. I.
- Abstract
The proapoptotic effect of anphen (the effect on the level of the antiapoptotic protein Bcl-2) was investigated by immunoblotting. Incubation of Lewis carcinoma cell suspension with anphen at a concentration of 10-6 M for 0-3 h caused a 80% reduction in the level of the Bcl-2 protein and its homodimer. In vivo, when administered for 4 days to outbred mice, anphen (10-4 M) induced a decrease in the level of the Bcl-2 homodimer in the spleen cells by 20% and an increase in the content of the Bad protein (apoptosis activator) and the Bcl-XL protein. The antitumor effect of anphen may be due to blocking the hydrophobic pocket of the Bcl-2 protein.
- Subjects
ANTINEOPLASTIC agents; PHENOLS; ANTIOXIDANTS; BCL-2 proteins; IMMUNOBLOTTING
- Publication
Doklady Biochemistry & Biophysics, 2018, Vol 482, Issue 1, p268
- ISSN
1607-6729
- Publication type
Article
- DOI
10.1134/S1607672918050101