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- Title
Estrogen Receptors alpha and beta in Ovarian Cancer: Expression Level and Prognosis.
- Authors
Bogush, T. A.; Basharina, A. A.; Bogush, E. A.; Ryabinina, O. M.; Tjulandina, A. S.; Tjulandin, S. A.
- Abstract
The quantitative immunofluorescence assay of serous ovarian cancer tissue for the expression of estrogen receptors (ERα and ERβ) revealed a higher expression level of ERβ in comparison with ERα in all surgical tumor samples investigated. Significant differences in the expression level of the markers were detected “from tumor to tumor.” A high expression level of both ERα (≥ 25%) and ERβ (≥ 44%) in the tumor predicts a significantly longer progression-free survival time (p < 0.01) in the patients after the first line of platinum and taxane-based adjuvant chemotherapy.
- Subjects
OVARIAN cancer; ESTROGEN receptors; IMMUNOFLUORESCENCE; TUMORS; CANCER chemotherapy
- Publication
Doklady Biochemistry & Biophysics, 2018, Vol 482, Issue 1, p249
- ISSN
1607-6729
- Publication type
Article
- DOI
10.1134/S1607672918050058