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- Title
RNA Oscillator: Limit Cycle Oscillations based on Artificial Biomolecular Reactions.
- Authors
Takinoue, Masahiro; Kiga, Daisuke; Shohda, Koh-ichiroh; Suyama, Akira
- Abstract
In recent years, various DNA nanomachines driven by DNA hybridizations have been developed as a remarkable application of DNA computers for nanotechnology. Here, we propose an oscillatory reaction system as a nano-sized nucleic acid engine to control the nanomachines. It utilizes DNA/RNA and their molecular reactions, and is modeled after the circadian rhythm in life systems. The molecular reactions consist of nucleic acid hybridization, RNA transcription, DNA extension, RNA degradation, and uracil-containing DNA degradation. Numerical analyses of rate equations for the reactions demonstrate that oscillatory conditions of the reaction system are determined by the balance between RNA influx into the system and RNA degradation out of the system. The analytical results will provide important information when the oscillator is constructed in in vitro experiments.
- Subjects
OSCILLATIONS; OSCILLATING chemical reactions; RNA; DNA; BIOMOLECULES; CIRCADIAN rhythms
- Publication
New Generation Computing, 2009, Vol 27, Issue 2, p107
- ISSN
0288-3635
- Publication type
Article
- DOI
10.1007/s00354-008-0057-5