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- Title
Increase in high molecular weight adiponectin by bariatric surgery-induced weight loss.
- Authors
Linscheid, P.; Christ-Crain, M.; Stoeckli, R.; Reusch, C. E.; Lutz, T. A.; Müller, B.; Keller, U.
- Abstract
Aim: To determine the changes in adiponectin multimers upon marked weight loss. Methods: Plasma samples were obtained preoperatively and 3, 6, 12 and 24 months after surgery from 12 obese subjects undergoing weight loss–inducing bariatric surgery. Seven non-operated obese subjects served as controls. Plasma levels of adiponectin multimers were determined by protease digestion and Enzyme-Linked ImmunoSorbent Assay (ELISA) detection. In addition, adiponectin multimers were assessed by western blotting. Results: In patients with weight loss after surgery but not in controls, total adiponectin and high molecular weight (HMW) adiponectin steadily increased during the observation period. Twenty-four months after surgery, the increase in total and HMW adiponectin was 2.2 ± 0.46 and 1.4 ± 0.3 μg/ml, respectively. In contrast, plasma concentrations of middle and low molecular weight adiponectin remained unchanged. Conclusions: The increase in plasma adiponectin levels observed 24 months after bariatric surgery depended on continuous weight loss and was completely attributable to the HMW complex.
- Subjects
BARIATRIC surgery; FAT cells; ADIPOSE tissues; WEIGHT loss; PLASMA confinement
- Publication
Diabetes, Obesity & Metabolism, 2008, Vol 10, Issue 12, p1266
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1111/j.1463-1326.2008.00899.x