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- Title
Synthesis and characterization of nano-hydroxyapatite in maltodextrin matrix.
- Authors
Bich T. N. Phan; Hanh T. Nguyen; Huong Q. Ðao; Lam V. Pham; Trang T. T. Quan; Duong B. Nguyen; Huong T. L. Nguyen; Thuan T. Vu
- Abstract
In this study, we report the direct precipitation of nano-HA in the present of maltodextrins with the different dextrose equivalent (DE) values in the range of 10-30. Characterization of the obtained samples, using X-ray diffraction and Fourier transform infrared spectrophotometry, indicated that the presence of maltodextrins, with the different DE values, does not affect the phase composition and structure of the obtained composites. Morphology studies of the samples, using field emission scanning electron microscope and transmission electron microscope, revealed that maltodextrin has obvious effect on the size, shape, and morphology of hydroxyapatite nanoparticles. In particular, in studied DE range, maltodextrin DE 28-30 with dominant structure of debranched chain is the most preferable choice to obtain the composite with highly dispersed nanoparticles. In vitro assay on pre-osteoblast MC3T3-E1 cells demonstrated the ability of the composites to stimulate alkaline phosphatase activity and mineralization during differentiation of the cells.
- Subjects
MALTODEXTRIN; HYDROXYAPATITE; NANOPARTICLES; DEXTROSE; X-ray diffraction; FOURIER transform infrared spectroscopy; CLUSTERING of particles
- Publication
Applied Nanoscience, 2017, Vol 7, Issue 1/2, p1
- ISSN
2190-5509
- Publication type
Article
- DOI
10.1007/s13204-016-0541-z