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- Title
Pharmacokinetics of tilmicosin in equine tissues and plasma.
- Authors
CLARK, C.; DOWLING, P. M.; ROSS, S.; WOODBURY, M.; BOISON, J. O.
- Abstract
The macrolide antibiotic tilmicosin has potential for treating bacterial respiratory tract infections in horses. A pharmacokinetic study evaluated the disposition of tilmicosin in the horse after oral (4 mg/kg) or subcutaneous (s.c.) (10 mg/kg) administration. Tilmicosin was not detected in equine plasma or tissues after oral administration at this dose. With s.c. injection, tilmicosin concentrations reached a maximum concentration of approximately 200 ng/mL in the plasma of the horses. Tilmicosin concentrations in plasma persisted with a mean residence time ( MRT) of 19 h. Maximum tissue residue concentrations ( Cmax) of tilmicosin measured in equine lung, kidney, liver and muscle tissues after s.c. administration were 2784, 4877, 1398, and 881 ng/g, respectively. The MRT of tilmicosin in these tissues was approximately 27 h. Subcutaneous administration of tilmicosin resulted in severe reactions at the injection sites.
- Subjects
ANTIBIOTICS; MACROLIDE antibiotics; BLOOD plasma; PHARMACOKINETICS; INFECTION
- Publication
Journal of Veterinary Pharmacology & Therapeutics, 2008, Vol 31, Issue 1, p66
- ISSN
0140-7783
- Publication type
Article
- DOI
10.1111/j.1365-2885.2007.00909.x