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- Title
Sustained virological response to interferon reduces cirrhosis in chronic hepatitis C: a 1386-patient study from Taiwan.
- Authors
HUANG, J.‐F.; YU, M.‐L.; LEE, C.‐M.; DAI, C.‐Y.; HOU, N.‐J.; HSIEH, M.‐Y.; WANG, J.‐H.; LU, S.‐N.; SHEEN, I.‐S.; LIN, S.‐M.; CHUANG, W.‐L.; LIAW, Y.‐F.
- Abstract
Background The long-term benefits of interferon-based therapy on preventing cirrhosis at non-cirrhotic stage in chronic hepatitis C patients are not fully clarified. Aim To evaluate the effectiveness of interferon-based therapy regarding to cirrhosis prevention in non-cirrhotic chronic hepatitis C patients. Methods A total of 1386 biopsy-proven, non-cirrhotic chronic hepatitis C patients (892 received interferon-based therapy and 494 untreated) were enrolled. Results Fifty-six untreated and 51 treated (24 sustained virologic responders and 27 non-responders) patients developed cirrhosis during a mean follow-up period of 5.0 (1–16) and 5.1 (1–15.3) years, respectively. The annual incidences of cirrhosis in untreated and treated groups were 2.26 and 1.11% (non-responders: 1.99%, sustained responders: 0.74%), respectively. The 15-year cumulative incidence of cirrhosis was significantly lower in treated (9.9%) than untreated patients (39.8%, P = 0.0008, log-rank test). The 14.5-year cumulative incidence of cirrhosis was significantly lower in sustained responders (4.8%) compared with non-responders (21.6%, P = 0.0007) and untreated patients (36.6%, P < 0.0001). The difference was not significant between non-responders and untreated controls. Cox proportional hazards regression showed sustained virologic responders and younger age were independent negative factors for cirrhosis development. Conclusion A sustained virologic response secondary to IFN-based therapy could reduce cirrhosis development in chronic hepatitis C patients.
- Subjects
TAIWAN; THERAPEUTIC use of interferons; VIROLOGY; HEPATITIS C; CIRRHOSIS of the liver
- Publication
Alimentary Pharmacology & Therapeutics, 2007, Vol 25, Issue 9, p1029
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2007.03297.x