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- Title
The Prognostic Role of Circulating Epstein-Barr Virus DNA Copy Number in Angioimmunoblastic T-Cell Lymphoma Treated with Dose-Adjusted EPOCH.
- Authors
Jin-Hua Liang; Luo Lu; Hua-Yuan Zhu; Wang Li; Lei Fan; Jian-Yong Li; Wei Xu
- Abstract
Purpose Determine the frequency and prognostic value of circulating Epstein-Barr virus (EBV) DNA copy number in angioimmunoblastic T-cell lymphoma (AITL) patients who were treated with dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin (DA-EPOCH) regimens. Materials and Methods Sixty newly-diagnosed AITL patients were retrospectively enrolled in the present study. All patients were treated with DA-EPOCH regimen. Results Twenty-two subjects (36.7%) had a EBV DNA-positive test at diagnosis. EBV DNA-positive patients were associated with lower lymphocyte-monocyte ratio (p=0.024). Median followup was 40 months (range, 14 to 100 months). The overall response rate for all the 60 AITL patents were 71.7% (95% confidence interval [CI], 58.6 to 82.5) with 3-year progressivefree survival (PFS) rate of 30.9%±6.1% and overall survival (OS) rate of 60.1%±6.6%. Not only did PFS estimation differ between the EBV DNA-positive and EBV DNA-negative group (hazard ratio [HR], 2.24,95% CI, 1.15 to 4.35,p=0.006), but also worse OS was observed in the pretreatment EBV DNA-positive group than in the EBV DNA-negative group (HR, 2.74,95% CI, 1.22 to 6.19,p=0.006). EBV DNA test positivity was independent prognostic marker for both PFS (HR, 2.17,95% CI, 1.17 to 4.00,p=0.014) and OS (HR, 3.24,95% CI, 1.48 to 7.11,p=0.004) after adjusting International Prognostic Index and prognostic index for AITL score. Reduction in EBV copies was significantly associated with therapy-response. Conclusion Circulating EBV DNA level was an important prognostic and monitoring marker for AITL patients who treated with DA-EPOCH regimens which cannot improve outcomes for AITL patients.
- Subjects
CIRCULATING tumor DNA; T-cell lymphoma; EPSTEIN-Barr virus; DNA viruses
- Publication
Cancer Research & Treatment, 2019, Vol 51, Issue 1, p150
- ISSN
1598-2998
- Publication type
Article
- DOI
10.4143/crt.2017.476