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- Title
Multiomics integration for the function of bacterial outer membrane vesicles in the larval settlement of marine sponges.
- Authors
Beibei Zhang; Chenzheng Jia; Mingyu Li; Kai Wang; Jun Chen; Jing Zhao
- Abstract
Bacterial outer membrane vesicles (OMVs) contain a variety of chemical compounds and play significant roles in maintaining symbiotic relationships in a changing ocean, but little is known about their function, particularly in sponge larval development. During the growth of sponge Tedania sp., OMVs from Bacteroidetes species significantly promoted larval settlement, and Tenacibaculum mesophilum SP-7-OMVs were selected as a representative strain for further investigation. According to OMVs metabolomics, larval settlement might be connected to organic acids and derivatives. The multiomics analysis of the T. mesophilum genome, SP-7-OMVs metabolome, and larval transcriptome revealed 47 shared KEGG pathways. Among the number of candidate metabolites, arginine was chosen for its greater ability to increase the settlement rate and its role as the principal substrate for nitric oxide (NO) synthesis of sponge larvae. In summary, these results demonstrated that sponge-associated bacteria might utilize OMVs and their cargo to support host development and make up for host metabolic pathway deficiencies. This study enhances our fundamental knowledge of OMVs in interactions between metazoan hosts andmicroorganisms that are crucial in the coevolution of marine ecosystems and the complex marine environment.
- Subjects
EXTRACELLULAR vesicles; MULTIOMICS; SPONGES (Invertebrates); ACID derivatives; LARVAL dispersal; MARINE ecology; ARGININE; BACTERIAL cell walls; ASYMMETRIC dimethylarginine
- Publication
Frontiers in Microbiology, 2024, p1
- ISSN
1664-302X
- Publication type
Article
- DOI
10.3389/fmicb.2024.1268813