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- Title
Two Cases of Dedifferentiated Chordoma in the Sacrum.
- Authors
Seon Chun Kim; Wonik Cho; Ung-Kyu Chang; Sang Min Youn
- Abstract
Dedifferentiated chordoma (DC) is defined as a chordoma containing sarcoma components. DC is distinguished from conventional chordoma by the rapidity of tumor growth and the potential for distant metastasis. We report two cases of DC, which are developed in the sacrum. We reviewed the medical records and imaging studies of 2 patients diagnosed with DC and the literature published. In the first case, percutaneous biopsy revealed that it was conventional chordoma in the sacrum. Patient underwent radiation therapy (RT). Six years after the RT, the tumor recurred. Surgical removal was performed and the recurrent tumor was diagnosed as DC in histopathologic examination. In the second case, a patient underwent gross total resection of sacral tumor, which was diagnosed with conventional chordoma. Aggravated tumor was detected after 4 months, and patient underwent reoperation. The second operation revealed the transformation of the tumor into DC. The survival time of the patients after the diagnosis was 10 and 31 months. Dedifferentiated chordoma is a rare and highly aggressive tumor. De novo type exists, but it usually transformed from recurrent chordoma after surgical resection or radiation.
- Subjects
SACRUM diseases; CHORDOMA; SPINE cancer
- Publication
Korean Journal of Spine, 2015, Vol 12, Issue 3, p230
- ISSN
1738-2262
- Publication type
Case Study
- DOI
10.14245/kjs.2015.12.3.230