We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Comparative Effects of Gymnema sylvestre and Berberine on Adipokines, Body Composition, and Metabolic Parameters in Obese Patients: A Randomized Study.
- Authors
Bandala, Cindy; Carro-Rodríguez, Jazmín; Cárdenas-Rodríguez, Noemí; Peña-Montero, Itzel; Gómez-López, Modesto; Hernández-Roldán, Ana Paola; Huerta-Cruz, Juan Carlos; Muñoz-González, Felipe; Ignacio-Mejía, Iván; Domínguez, Brayan; Lara-Padilla, Eleazar
- Abstract
Gymnema sylvestre (GS) and berberine (BBR) are natural products that have demonstrated therapeutic potential for the management of obesity and its comorbidities, as effective and safe alternatives to synthetic drugs. Although their anti-obesogenic and antidiabetic properties have been widely studied, comparative research on their impact on the gene expression of adipokines, such as resistin (Res), omentin (Ome), visfatin (Vis) and apelin (Ap), has not been reported. Methodology: We performed a comparative study in 50 adult Mexican patients with obesity treated with GS or BBR for 3 months. The baseline and final biochemical parameters, body composition, blood pressure, gene expression of Res, Ome, Vis, and Ap, and safety parameters were evaluated. Results: BBR significantly decreased (p < 0.05) body weight, blood pressure and Vis and Ap gene expression and increased Ome, while GS decreased fasting glucose and Res gene expression (p < 0.05). A comparative analysis of the final measurements revealed a lower gene expression of Ap and Vis (p < 0.05) in patients treated with BBR than in those treated with GS. The most frequent adverse effects in both groups were gastrointestinal symptoms, which attenuated during the first month of treatment. Conclusion: In patients with obesity, BBR has a better effect on body composition, blood pressure, and the gene expression of adipokines related to metabolic risk, while GS has a better effect on fasting glucose and adipokines related to insulin resistance, with minimal side effects.
- Subjects
ADIPOKINES; PREPROCEDURAL fasting; ALKALOIDS; MEXICANS; RESEARCH funding; STATISTICAL sampling; BODY composition; PHYTOCHEMICALS; RANDOMIZED controlled trials; DESCRIPTIVE statistics; REVERSE transcriptase polymerase chain reaction; BIOCHEMISTRY; HYPOGLYCEMIC agents; PLANT extracts; GENE expression; EXPERIMENTAL design; INSULIN resistance; MEDICINAL plants; ANTIOBESITY agents; BLOOD pressure; COMPARATIVE studies; OBESITY; COMORBIDITY; BLOOD sugar monitoring; RESISTIN; PHARMACODYNAMICS
- Publication
Nutrients, 2024, Vol 16, Issue 14, p2284
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16142284