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- Title
Fermented Rice Bran Supplementation Inhibits LPS-Induced Osteoclast Formation and Bone Resorption in Mice.
- Authors
Noguchi, Takahiro; Kitaura, Hideki; Marahleh, Aseel; Agista, Afifah Zahra; Ohsaki, Yusuke; Shirakawa, Hitoshi; Mizoguchi, Itaru
- Abstract
Fermented rice bran (FRB) is known to have numerous beneficial bioactivities, amongst which is its anti-inflammatory properties when used as a supplement. To determine its effects, we examined osteoclastogenesis and bone resorption caused by injections of lipopolysaccharide (LPS), using mice with and without FRB supplementation. The results were favorable: those that received FRB showed reduced osteoclast numbers and bone resorption compared to those with the control diet. Notably, receptor activator of NF-κB ligand (RANKL) and tumor necrosis factor-α (TNF-α) mRNA levels were shown to be lower in the LPS-treated animals with FRB supplementation. FRB's inhibitory effect on RANKL- and TNF-α-induced osteoclastogenesis was further confirmed in vitro. In culture, macrophages exhibited decreased TNF-α mRNA levels when treated with FRB extract and LPS versus treatment with LPS alone, but there was no significant change in RANKL levels in osteoblasts. We can conclude that FRB supplementation dampens the effect of LPS-induced osteoclastogenesis and bone resorption by controlling TNF-α expression in macrophages and the direct inhibition of osteoclast formation.
- Subjects
RICE; LIPOPOLYSACCHARIDES; BIOLOGICAL models; IN vitro studies; CELL differentiation; BONE growth; INJECTIONS; OSTEOCLASTS; BONE resorption; ANIMAL experimentation; MACROPHAGES; CELL receptors; DIETARY supplements; TREATMENT effectiveness; COMPARATIVE studies; DESCRIPTIVE statistics; TUMOR necrosis factors; MESSENGER RNA; RESEARCH funding; FERMENTATION; MICE
- Publication
Nutrients, 2023, Vol 15, Issue 13, p3044
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15133044