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- Title
Effects of Endurance Exercise and Vitamin D Supplementation on Insulin Resistance and Plasma Lipidome in Middle-Aged Adults with Type 2 Diabetes.
- Authors
Sun, Xiaomin; Yan, Tao; Li, Zhongying; Zhou, Sirui; Peng, Wen; Cui, Wei; Xu, Jing; Cao, Zhen-Bo; Shi, Lin; Wang, Youfa
- Abstract
(1) Background: We investigated the effects of a 12-week exercise intervention with or without vitamin D supplementation on insulin resistance and the plasma lipidome of participants with type 2 diabetes. We further explored whether the effects of the intervention on glycemic parameters could be associated with the baseline lipidome. (2) Methods: Sixty-one participants were randomly allocated to control (Con), exercise (EX), vitamin D (VD), and EX + VD groups. Multiple glycemic and anthropometric parameters were evaluated before and after intervention. The homeostasis model assessment of insulin resistance (HOMA-IR) was the primary outcome. The plasma lipidome was analyzed before, after, and at an additional 12-week follow-up. Machine learning was applied to establish prediction models for responsiveness of glycemic control. (3) Results: Our interventions failed to improve the HOMA-IR index while fasting glucose was reduced in the EX + VD group (change%, −11.9%; effect size, 0.65; p < 0.05). Both EX and VD interventions altered the plasma lipidome, with EX + VD intervention considerably affecting levels of lyso-phosphatidylcholines and triglycerols containing long-chain unsaturated fatty acids. Such effects could last until 12 weeks after intervention. Notably, there was high inter-individual variability in glycemic parameters including HOMA-IR in response to the interventions, which could be predicted with great accuracy using an optimal panel of baseline lipid predictors alone or in combination with clinical indices, as assessed by an area under the receiver operating characteristic curve value of over 0.9. (4) Conclusions: Although substantial alterations were observed in the plasma lipidome related to glycemic control, our intervention failed to improve HOMA-IR scores, which may have been predominately due to the large inter-individual variability in responses. Basal plasma lipid levels could potentially predict an individual's response to intervention, highlighting the necessity of personalized nutrition.
- Subjects
THERAPEUTIC use of vitamin D; UNSATURATED fatty acids; TRIGLYCERIDES; ENDURANCE sports training; ANTHROPOMETRY; GLYCEMIC control; METABOLOMICS; MACHINE learning; BLOOD sugar; DIETARY supplements; TYPE 2 diabetes; TREATMENT effectiveness; RANDOMIZED controlled trials; PRE-tests &; post-tests; DESCRIPTIVE statistics; STATISTICAL sampling; PREDICTION models; RECEIVER operating characteristic curves; INSULIN resistance; LIPIDS; LECITHIN; MIDDLE age
- Publication
Nutrients, 2023, Vol 15, Issue 13, p3027
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15133027