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- Title
Citrulline, Intestinal Fatty Acid-Binding Protein and the Acute Gastrointestinal Injury Score as Predictors of Gastrointestinal Failure in Patients with Sepsis and Septic Shock.
- Authors
Tyszko, Maciej; Lemańska-Perek, Anna; Śmiechowicz, Jakub; Tomaszewska, Paulina; Biecek, Przemyslaw; Gozdzik, Waldemar; Adamik, Barbara
- Abstract
Gastrointestinal (GI) failure can be both a cause of sepsis and a consequence of the systemic pro-inflammatory response in sepsis. Changes in biomarkers of enterocyte damage, citrulline and I-FABP (intestinal fatty acid binding protein), may indicate altered intestinal permeability and damage. The study group consisted of patients with sepsis (N = 28) and septic shock (N = 30); the control group included patients without infection (N = 10). Blood samples were collected for citrulline and I-FABP and a 4-point AGI score (acute GI injury score) was calculated to monitor GI function on days 1, 3, 5, 7, and 10. Citrulline concentrations in the study group were lower than in the control. Lower values were also noted in septic patients with shock when compared to the non-shock group throughout the study period. I-FABP was higher in the septic shock group than in the sepsis group only on days 1 and 3. Citrulline was lower in patients with GI failure (AGI III) when compared to AGI I/II, reaching significance on days 7 (p = 0.034) and 10 (p = 0.015); moreover, a higher AGI score was associated with an increased 28 day mortality (p = 0.038). The results indicate that citrulline measurements, along with the AGI assessment, have clinical potential in monitoring GI function and integrity in sepsis.
- Subjects
GASTROINTESTINAL system injuries; BIOMARKERS; NONPARAMETRIC statistics; SCIENTIFIC observation; HUMAN research subjects; ANALYSIS of variance; CONFIDENCE intervals; FATTY acid-binding proteins; GASTROINTESTINAL diseases; APACHE (Disease classification system); MANN Whitney U Test; SEPSIS; INFORMED consent (Medical law); CRITICAL care medicine; CHI-squared test; KAPLAN-Meier estimator; DESCRIPTIVE statistics; RESEARCH funding; AMINO acids; ODDS ratio; DATA analysis software; FRIEDMAN test (Statistics); LOGISTIC regression analysis; SEPTIC shock; LONGITUDINAL method; DISEASE complications
- Publication
Nutrients, 2023, Vol 15, Issue 9, p2100
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15092100