We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Prognostic Impact of Nutritional Status on Overall Survival and Health-Related Quality of Life in Men with Advanced Prostate Cancer.
- Authors
Cavka, Luka; Pohar Perme, Maja; Rotovnik Kozjek, Nada; Seruga, Bostjan
- Abstract
Purpose: Prognostic role of nutritional status (NS) in patients with metastatic castrate-resistant prostate cancer (mCRPC) is unknown. We hypothesized that patients' NS at the presentation of mCRPC is prognostic for health-related quality of life (HRQoL) and overall survival (OS). Methods: We conducted a prospective observational study in mCRPC patients. At enrollment, we allocated each patient into one of four NS categories: (i) well-nourished (WN), (ii) nutritional risk without sarcopenia/cachexia (NR), (iii) sarcopenia, or (iv) cachexia. We sought the prognostic role of the NS for OS and HRQoL by regression models. Results: 141 patients were included into our study. When compared to WN patients, those with NR and cachexia had a higher chance of worse HRQoL (OR 3.45; 95% CI [1.28 to 9.09], and OR 4.17; 95% CI [1.28 to 12.5], respectively), as well as shorter OS (HR 2.04; 95% CI [1.19 to 3.39] and HR 2.9; 95% CI [1.56 to 5.41], respectively). However, when accounting for possible confounding factors, we could not prove the significant importance of NS for chosen outcomes. Conclusions: Suboptimal NS might be an unfavorable prognostic factor for HRQoL and OS. Further interventional studies focusing on therapy or prevention are warranted.
- Subjects
SCIENTIFIC observation; CONFIDENCE intervals; METASTASIS; HEALTH status indicators; MEN; REGRESSION analysis; CASTRATION-resistant prostate cancer; RISK assessment; QUALITY of life; SURVIVAL analysis (Biometry); DESCRIPTIVE statistics; MALNUTRITION; RESEARCH funding; ODDS ratio; NUTRITIONAL status; LONGITUDINAL method; DISEASE risk factors
- Publication
Nutrients, 2023, Vol 15, Issue 4, p1044
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15041044