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- Title
One-Carbon Metabolism Biomarkers and Risks of Incident Neurocognitive Disorder among Cognitively Normal Older Adults.
- Authors
Przybycien-Gaweda, Paulina Maria; Lee, Tih Shih; Lim, Wee Shiong; Chong, Mei Sian; Yap, Philip; Cheong, Chin Yee; Rawtaer, Iris; Liew, Tau Ming; Gwee, Xinyi; Gao, Qi; Yap, Keng Bee; Ng, Tze Pin
- Abstract
There is a lack of evidence supporting an association between folate and vitamin B12 exposure with cognitive outcomes. We examined serum folate and vitamin B12 and plasma homocysteine in 690 cognitively-normal adults (aged ≥ 55) from the Singapore Longitudinal Aging Study (SLAS-2) followed-up over 4.5 years on incident neurocognitive disorder (NCD): mild cognitive impairment (MCI) and dementia. At follow-up, 5.7% (39) of participants developed NCD (34 MCI and 5 dementia). Comparing with those who remained cognitively-normal, participants progressed to NCD had significantly lower mean baseline vitamin B12 (420 [SD ± 221] vs. 510 [SD ± 290] pmol/L, p = 0.026), higher homocysteine (14.6 [SD ± 4.2] vs. 12.9 [SD ± 4.3], p = 0.018) and lower one-carbon index (Z-scores: −0.444 [SD ± 0.819] vs. −0.001 [SD ± 0.990], p = 0.006). Adjusted for confounders, significant associations with incident NCD were found for lower vitamin B12 (per-SD OR = 2.10, 95%CI = 1.26–3.52), higher homocysteine (per-SD OR = 1.96, 95%CI = 1.18–3.24) and lower one-carbon index (per-SD OR = 1.67, 95%CI = 1.06–2.64). Folate was not significantly associated with progression to NCD. Notably, low B12 in the presence of high folate was significantly associated with incident NCD (adjusted OR = 3.81, 95%CI = 1.04–13.9). Low B12, high homocysteine, low B12 in the presence of high folate, and a one-carbon index of hypo-methylation were independently associated with progression to NCD among cognitively normal.
- Subjects
HOMOCYSTEINE; NEUROLOGICAL disorders; VITAMIN B12; CONFIDENCE intervals; COGNITION; RISK assessment; DESCRIPTIVE statistics; FOLIC acid; ODDS ratio; DISEASE risk factors; MIDDLE age; OLD age
- Publication
Nutrients, 2022, Vol 14, Issue 17, p3535
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14173535