We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Fluoride Status and Cardiometabolic Health: Findings from a Representative Survey among Children and Adolescents.
- Authors
Ballantyne, Jessica A.; Coyle, Gemma; Sarwar, Sneha; Kühn, Tilman
- Abstract
There is preliminary evidence to suggest a positive association between fluoride exposure and higher blood pressure among children, but population-based biomarker studies are lacking. Thus, data from the 2013/2014 and 2015/2016 cycles of the US-based National Health and Nutrition Examination Survey (NHANES) were analysed to evaluate the association between plasma fluoride concentrations and blood pressure among children and adolescents aged 8 to 19 years. Secondary analyses were carried out on fluoride status in relation to further markers of cardio-metabolic health, i.e., anthropometric indices, biomarkers of lipid and sugar metabolism, and C-reactive protein levels. There was a positive correlation between water fluoride content and plasma fluoride concentrations (Spearman's r = 0.41, p < 0.01). However, multivariable linear regression models did not show significant differences in adjusted mean values of systolic and diastolic blood pressure across increasing quartiles of fluoride concentrations. Further markers of cardio-metabolic health were not associated with fluoride status, with the exception of a weak inverse association between plasma fluoride and HbA1c levels. Higher plasma fluoride may not be a risk factor for increased blood pressure or impaired cardio-metabolic health among children in the USA, a non-fluoride endemic country, with wide-spread water fluoridation.
- Subjects
BLOOD pressure; CARDIOVASCULAR diseases risk factors; BIOMARKERS; C-reactive protein; GLYCOSYLATED hemoglobin; STATISTICS; FLUORIDES; ANTHROPOMETRY; MULTIVARIATE analysis; REGRESSION analysis; SURVEYS; DESCRIPTIVE statistics; STATISTICAL correlation; DATA analysis; SECONDARY analysis; LIPIDS
- Publication
Nutrients, 2022, Vol 14, Issue 7, p1459
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14071459